January 31, 2019
Tao Ye group’s latest work on how DNA biosensors operate at the single molecule level was published in the Journal of the American Chemical Society. DNA biosensors use DNA probes immobilized on a solid support to recognize biomarkers. By using high resolution imaging technique to image single molecules on a working biosensor at the nanoscale, the Ye group discovered an unexpected cooperative effect: the DNA probe molecules in proximity may enhance the rate of biomarker recognition. The discovery may help make these DNA biosensors more sensitive and reproducible.
