Chemical Biology

 

Three proteins (KaiA, KaiB, and KaiC) of the cyanobacterial circadian clock that form a self-sustained circadian oscillator when combined with ATP, courtesy of Prof. A LiWang

Experimental, computational and theoretical methods and techniques from chemistry have played crucial roles in the elucidation of the molecular basis of life. Challenges posed by specific biological problems are driving the development of new analytical tools and prompting advances in the physical and chemical sciences. Chemists increasingly take inspiration from and/or directly use biological processes to develop structures and materials with novel chemical functions. A number of our faculty members work at this dynamic interface between chemistry and biology. The Colvin group works on modeling semi-structured biomolecular systems, while the Isborn group models how biological systems, like light harvesting proteins and photoreceptor proteins, interact with light. The A. LiWang group is resolving the structural and biochemical basis of rhythmicity of the circadian clock, which is used for time keeping in life cycles. The P. LiWang group determines the structure of chemokines and how they affect HIV and inflammatory diseases. The Meyer group is developing a new technique to probe the interactions between small molecules and enzymes. The Noy group studies molecular transport and signal transduction across nanoscale interfaces and develops biomimetic nanostructures that facilitate the creation of bioelectronic devices and circuits. The Ye group is engaged in the hierarchical self-assembly of nucleic acid nanostructures as well as the development of new tools to analyze single DNA molecules.

Image: Three proteins of the cyanobacterial circadian clock that form a self-sustained circadian oscillator when combined with ATP, courtesy of Professor Andy LiWang.

 

Representative Publications

  • Roger, T., Chang, Y. -G., Bravo, I., Latham, R., Chaudhary, A., Kuo, N. -W., LiWang, A. Cooperative KaiA-KaiB-KaiC interactions affect KaiB/SasA competition in the circadian clock of cyanobacteria, J. Mol. Biol., 426, 389-402. (2014)
     
  • R. Tunuguntla, M. Bangar, K. Kim, P. Stroeve, C.M. Ajo-Franklin, A. Noy, Lipid Bilayer Composition can Influence the Orientation of Proteorhodopsin in Artificial Membranes, Biophys. J., v. 105, p. 1388 (2013)
     
  • Gary R. Abel, Eric A. Josephs, Norman Luong, and Tao Ye. A switchable surface enables visualization of single DNA hybridization events with atomic force microscopy. J. Am. Chem. Soc., 135, 6399-6402(2013)
     
  • Eric A. Josephs and Tao Ye. Nanoscale spatial distribution of thiolated DNA on model nucleic acid sensor surfaces. ACS Nano, 7, 3653-3660(2013)
     
  • C. M. Isborn, A. W. Götz, M. A. Clark, R. C. Walker, and T. J. Martínez. Electronic Absorption Spectra from MM and ab initio QM/MM Molecular Dynamics: Environmental Effects on the Absorption Spectrum of Photoactive Yellow Protein. J. Chem. Theory Comput., 8, pp 5092–5106 (2012)
     
  • Eric Josephs and Tao Ye. A Single-molecule view of conformational switching of DNA tethered to a gold electrode. J. Am. Chem. Soc.,134, 10021–10030 (2012)
     
  • Lu Zhang, Justin A. Kerszulis, Ronald J. Clark, Tao Ye , Lei Zhu. Catechol boronate formation and its electrochemical oxidation. Chem. Commun. 5491–5495 (2009)

 

Contact Us

Chemistry Undergraduate and Graduate Group Chair

Erik Menke, emenke@ucmerced.edu

 
Chemistry Bylaw Unit Chair

Anne Kelley, amkelley@ucmerced.edu

 
Mailing Address
University of California, Merced
5200 North Lake Road
Merced, CA 95343

 

 
University of California, Merced
 
The first new American research
university in the 21st century, with a
mission of research, teaching and service.
 
University of California, Merced
5200 North Lake Road
Merced, CA 95343
T: (209) 228-4400
 
University of California

 

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